IL1A Protein (AA 1-271)

Catalog No. ABIN7505592

Recombinant IL1A protein expressed in HEK-293 Cells.

Quick Overview for IL1A Protein (AA 1-271) (ABIN7505592)

Target: IL1A (Interleukin 1 alpha (IL1A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 1-271

Sequence: Met1-Ala271

Characteristics: A DNA sequence encoding the Human IL-1α protein (P01583) (1-271) was expressed with a polyhistidine tag at the C-terminus.

Endotoxin Level: <1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IL1A (Interleukin 1 alpha (IL1A))

Alternative Name: IL-1alpha

Background:

Abbreviation: IL-1α

Target Synonym: IL-1 alpha,Hematopoietin-1,IL1A,IL1F1,Interleukin-1 alpha,IL1a

Background: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Molecular Weight:

Calculated MW: 30.6 kDa

Observed MW: 35 kDa

UniProt: P01583

Pathways: NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints