CCL21 Protein

Catalog No. ABIN7536432

This Recombinant CCL21 protein is expressed in Yeast (Pichia pastoris).

Quick Overview for CCL21 Protein (ABIN7536432)

Target: CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))

Protein Type: Recombinant

Origin: Human

Source: Yeast (Pichia pastoris)

Purity: > 92 % by SDS-PAGE.

Product Details

Purpose: Recombinant Human CCL21/6Ckine Protein

Sequence: SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCK RTERSQTPKG P

Specificity: Ser24-Pro134

Sterility: 0.22 μm filtered

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

Concentration: 0.4 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))

Alternative Name: CCL21/6Ckine

Background:

Description: Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 21(CCL21), also known as 6Ckine, exodus-2, and secondary lymphoid-tissue chemokine(SLC), is a small cytokine belonging to the C-C chemokine family. CCL21 takes its name 6Ckine for its consititutively six conserved cysteine residues but not four cysteines typical to chemokines. CCL21 has function in ininducing vigorous calcium migrations and chemotactic responses.

Name: CCL21,6Ckine,CKb9,SCYA21

Gene ID: 6366

UniProt: O00585

Pathways: Regulation of Actin Filament Polymerization