FKBP1A Protein
Quick Overview for FKBP1A Protein (ABIN7533808)
Target
See all FKBP1A ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human FKBP1A/FKBP12 Protein
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Sequence
- MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE
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Specificity
- Met1-Glu108
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- < 0.1 EU/μg of the protein by LAL method.
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FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) protein (GST tag)
FKBP1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) protein (His-IF2DI Tag)FKBP1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) protein (His tag)FKBP1A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
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Buffer
- Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.
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Storage
- -20 °C,-80 °C
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Storage Comment
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
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Alternative Name
- FKBP1A/FKBP12
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Background
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Description: The protein is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor.
Name: FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE,FKBP1A,FKBP-1A,FKBP1,FKBP12,PKC12,PKCI2,PPIASE
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Gene ID
- 2280
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UniProt
- P62942
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Pathways
- Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
Target
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