Nectin-2 Protein (NECTIN2) (His tag)

Catalog No. ABIN7535985

This Recombinant Nectin-2 protein is produced in HEK-293 Cells.

Quick Overview for Nectin-2 Protein (NECTIN2) (His tag) (ABIN7535985)

Target: Nectin-2 (NECTIN2)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % by SDS-PAGE.

Product Details

Purification tag / Conjugate: This Nectin-2 protein is labelled with His tag.

Purpose: Recombinant Mouse Nectin-2/PVRL2/CD112 Protein

Sequence: QDVRVRVLPE VRGRLGGTVE LPCHLLPPTT ERVSQVTWQR LDGTVVAAFH PSFGVDFPNS QFSKDRLSFV RARPETNADL RDATLAFRGL RVEDEGNYTC EFATFPNGTR RGVTWLRVIA QPENHAEAQE VTIGPQSVAV ARCVSTGGRP PARITWISSL GGEAKDTQEP GIQAGTVTII SRYSLVPVGR ADGVKVTCRV EHESFEEPIL LPVTLSVRYP PEVSISGYDD NWYLGRSEAI LTCDVRSNPE PTDYDWSTTS GVFPASAVAQ GSQLLVHSVD RMVNTTFICT ATNAVGTGRA EQVILVRESP STAGAGATGG

Specificity: Gln32-Gly351

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: Nectin-2 (NECTIN2)

Alternative Name: Nectin-2/PVRL2/CD112

Background:

Description: Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+?T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Name: CD112,Nectin-2,PVRL2,PVRL2

Gene ID: 19294

UniProt: P32507-1