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Nectin-2 Protein (NECTIN2) (Fc Tag)

NECTIN2 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7319926
  • Target See all Nectin-2 (NECTIN2) products
    Nectin-2 (NECTIN2)
    Protein Type
    Recombinant
    Origin
    • 1
    • 1
    Human
    Source
    • 2
    Human Cells
    Purification tag / Conjugate
    This Nectin-2 protein is labelled with Fc Tag.
    Purpose
    Recombinant Human PVRL2/Nectin-2/CD112 (C-mIgG2a Fc)
    Sequence
    Gln32-Leu360
    Characteristics
    Recombinant Human Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Leu360 is expressed with a mIgG2a Fc tag at the C-terminus.
    Purity
    >95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Nectin-2 (NECTIN2)
    Alternative Name
    PVRL2/Nectin-2/CD112 (NECTIN2 Products)
    Synonyms
    CD112 Protein, HVEB Protein, PRR2 Protein, PVRR2 Protein, AI325026 Protein, AI987993 Protein, Cd112 Protein, MPH Protein, Pvr Protein, Pvs Protein, nectin-2 Protein, nectin cell adhesion molecule 2 Protein, NECTIN2 Protein, Nectin2 Protein
    Background

    Background: CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

    Synonym: Poliovirus Receptor-Related Protein 2, Herpes Virus Entry Mediator B, Herpesvirus Entry Mediator B, HveB, Nectin-2, CD112, PVRL2, HVEB, PRR2

    Molecular Weight
    62.6 kDa
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