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P-Cadherin Protein (CDH3) (His tag)

This Recombinant P-Cadherin protein is produced in HEK-293 Cells.
Catalog No. ABIN7520380

Quick Overview for P-Cadherin Protein (CDH3) (His tag) (ABIN7520380)

Target

See all P-Cadherin (CDH3) Proteins
P-Cadherin (CDH3)

Protein Type

Recombinant

Biological Activity

Active

Origin

  • 13
  • 7
  • 2
  • 1
Human

Source

  • 12
  • 6
  • 3
  • 1
  • 1
HEK-293 Cells

Purity

> 85 % by SDS-PAGE.
  • Purification tag / Conjugate

    This P-Cadherin protein is labelled with His tag.

    Purpose

    Active Recombinant Human CDH3/P-cadherin Protein

    Sequence

    DWVVAPISVP ENGKGPFPQR LNQLKSNKDR DTKIFYSITG PGADSPPEGV FAVEKETGWL LLNKPLDREE IAKYELFGHA VSENGASVED PMNISIIVTD QNDHKPKFTQ DTFRGSVLEG VLPGTSVMQV TATDEDDAIY TYNGVVAYSI HSQEPKDPHD LMFTIHRSTG TISVISSGLD REKVPEYTLT IQATDMDGDG STTTAVAVVE ILDANDNAPM FDPQKYEAHV PENAVGHEVQ RLTVTDLDAP NSPAWRATYL IMGGDDGDHF TITTHPESNQ GILTTRKGLD FEAKNQHTLY VEVTNEAPFV LKLPTSTATI VVHVEDVNEA PVFVPPSKVV EVQEGIPTGE PVCVYTAEDP DKENQKISYR ILRDPAGWLA MDPDSGQVTA VGTLDREDEQ FVRNNIYEVM VLAMDNGSPP TTGTGTLLLT LIDVNDHGPV PEPRQITICN QSPVRQVLNI TDKDLSPHTS PFQAQLTDDS DIYWTAEVNE EGDTVVLSLK KFLKQDTYDV HLSLSDHGNK EQLTVIRATV CDCHGHVETC PGPWKGG

    Specificity

    Asp108-Gly654

    Sterility

    0.22 μm filtered

    Endotoxin Level

    <1EU/μg

    Biological Activity Comment

    Measured by the ability of the immobilized protein to support the adhesion of A431 human epithelial carcinoma cells. When 1x105 cells/well are added to rhP-CAD/Fc Chimera coated plates (10 μg/mL with 100 μL/well), approximately 50-60% will adhere after 1.5 hours at 37° C.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

    Buffer

    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • Target

    P-Cadherin (CDH3)

    Alternative Name

    CDH3/P-cadherin

    Background

    Description: Cadherin-3 (also known as P-cadherin)is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. In humans, cadherin-3 is only detected in a few organs. However, its overexpression is strongly associated with a poor prognosis in some solid tumors including breast, lung and pancreatic cancers.

    Name: CDH3,CDHP,HJMD,PCAD

    Gene ID

    1001

    UniProt

    P22223
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