PIN1 Protein
Quick Overview for PIN1 Protein (ABIN7533720)
Target
See all PIN1 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purpose
- Active Recombinant Human PIN1 Protein
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Sequence
- MADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGN SSSGGKNGQG EPARVRCSHL LVKHSQSRRP SSWRQEKITR TKEEALELIN GYIQKIKSGE EDFESLASQF SDCSSAKARG DLGAFSRGQM QKPFEDASFA LRTGEMSGPV FTDSGIHIIL RTE
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Specificity
- Met1-Glu163
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- < 0.1 EU/μg of the protein by LAL method.
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human CTNNB1 Protein at 2 μg/mL (100 μL/well) can bind PIN1 with a linear range of 7.8-164.3 ng/mL.
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Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-165) protein (His tag)
custom-made PIN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) protein (His tag)custom-made PIN1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) protein (His tag)PIN1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) protein (GST tag)PIN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) proteinPIN1 Origin: Human Host: Escherichia coli (E. coli) 95 % by SDS - PAGE SDS
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-165) (Active) protein (His tag)PIN1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95% by SDS-PAGE SDS, EAA Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
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Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
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Storage
- -20 °C,-80 °C
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Storage Comment
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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Alternative Name
- PIN1
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Background
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Description: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This protein is a nucleus protein which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers.
Name: PIN1,DOD,UBL5
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Gene ID
- 5300
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UniProt
- Q13526
Target
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