CA9 Protein (AA 38-398) (His tag)

Catalog No. ABIN7538160

This Recombinant CA9 protein is expressed in Mammalian Cells.

Quick Overview for CA9 Protein (AA 38-398) (His tag) (ABIN7538160)

Target: CA9 (Carbonic Anhydrase IX (CA9))

Protein Type: Recombinant

Origin: Cynomolgus

Source: Mammalian Cells

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 38-398

Purification tag / Conjugate: This CA9 protein is labelled with His tag.

Purpose: Recombinant Cynomolgus CA9 protein with C-terminal 10xHis tag

Specificity: CA9 (Gln38-Leu398) 10xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CA9 (Carbonic Anhydrase IX (CA9))

Alternative Name: CA9

Background: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]

Molecular Weight: predicted molecular mass of 41.0 kDa after removal of the signal peptide. The apparent molecular mass of cCA9-His is 35-55 kDa due to glycosylation.

UniProt: A0A2K5VQG9