CCBP2 Protein
Quick Overview for CCBP2 Protein (ABIN7538192)
Target
See all CCBP2 ProteinsProtein Type
Origin
Source
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Purpose
- Human ACKR2 full length protein-synthetic nanodisc
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Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Chemokine Binding Protein 2 (CCBP2) (AA 1-378) protein (His tag)
custom-made CCBP2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Chemokine Binding Protein 2 (CCBP2) (AA 1-384) protein (His tag)custom-made CCBP2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Chemokine Binding Protein 2 (CCBP2) (AA 1-384) protein (GST tag)CCBP2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Chemokine Binding Protein 2 (CCBP2) (AA 315-384) protein (His-IF2DI Tag)CCBP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Chemokine Binding Protein 2 (CCBP2) protein (Myc-DYKDDDDK Tag)CCBP2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- CCBP2 (Chemokine Binding Protein 2 (CCBP2))
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Alternative Name
- ACKR2
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Background
- This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members, however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
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Molecular Weight
- The human full length ACKR2 protein has a MW of 43.4kDa
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UniProt
- O00590
Target
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