FAM116A Protein (AA 1-608) (His tag)

Catalog No. ABIN7547038

This Recombinant FAM116A protein is produced in HEK-293 Cells.

Quick Overview for FAM116A Protein (AA 1-608) (His tag) (ABIN7547038)

Target: FAM116A (Family with Sequence Similarity 116, Member A (FAM116A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-608

Purification tag / Conjugate: This FAM116A protein is labelled with His tag.

Purpose: Predefined custom protein recombinant DENND6A Protein expressed in mammalian cells.

Sequence: MALRGPAGLG PGSRRPLDEA VAGAEGREAP ALVAAGGAPE DDEEDDGRGR GLLRWDSFSA WLHCVCVVGF DLELGQAVEV IYPQHSKLTD REKTNICYLS FPDSNSGCLG DTQFCFRFRQ SSGRRVSLHC LLDQFDKDLP VYLKKDPAYF YGYVYFRQVR DKTLKRGYFQ KSLVLISKLP YIHFFHTVLK QIAPEYFEKN EPYLEAACND VDRWPAPVPG KTLHLPIMGV VMKVRIPTCH DKPGTTQIVQ LTQQVDTNIS VILPTVHEVD IFRCFCPVFL HSQMLWELVL LGEPLVVMAP SPSESSETVL ALVNCISPLK YFSDFRPYFT IHDSEFKEYT TRTQAPPSVI LGVTNPFFAK TLQHWPHIIR IGDLKPTGEI PKQVKVKKLK NLKTLDSKPG VYTSYKPYLN RDEEIIKQLQ KGVQQKRPSE AQSVILRRYF LELTQSFIIP LERYVASLMP LQKSISPWKS PPQLRQFLPE EFMKTLEKTG PQLTSRIKGD WIGLYRHFLK SPNFDGWFKT RRKEMTQKLE ALHLEALCEE DLLLWIQKHT EVETVDLVLK LKNKLLQADR EHLPVKPDTM EKLRTHIDAI ILALPEDLQG ILLKTGMT Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: FAM116A (Family with Sequence Similarity 116, Member A (FAM116A))

Alternative Name: DENND6A

Background: Protein DENND6A (DENN domain-containing protein 6A),FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. {ECO:0000269|PubMed:22595670}.

Molecular Weight: 69.6 kDa

UniProt: Q8IWF6

AlphaFold: Q8IWF6