NEURL3 Protein (AA 1-262) (His tag)

Catalog No. ABIN7549735

This Recombinant NEURL3 protein is produced in HEK-293 Cells.

Quick Overview for NEURL3 Protein (AA 1-262) (His tag) (ABIN7549735)

Target: NEURL3 (Neuralized E3 Ubiquitin Protein Ligase 3 (NEURL3))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-262

Purification tag / Conjugate: This NEURL3 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant NEURL3 Protein expressed in mammalian cells.

Sequence: MGAQLCFEAN AKAPREALRF HAEAKGAQVR LDTRGCIAHR RTTFHDGIVF SQRPVRLGER VALRVLREES GWCGGLRVGF TRLDPACVSV PSLPPFLCPD LEEQSPTWAA VLPEGCALTG DLVRFWVDRR GCLFAKVNAG CRLLLREGVP VGAPLWAVMD VYGTTKAIEL LDPTASRLPT PMPWDLSNKA VPEPKATPGE ECAICFYHAA NTRLVPCGHT YFCRYCAWRV FSDTAKCPVC RWQIEAVAPA QGPPALRVEE GS Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: NEURL3 (Neuralized E3 Ubiquitin Protein Ligase 3 (NEURL3))

Alternative Name: NEURL3

Background: E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3),FUNCTION: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). {ECO:0000269|PubMed:30111563, ECO:0000269|PubMed:35792897}.

Molecular Weight: 28.8 kDa

UniProt: Q96EH8

AlphaFold: Q96EH8