CCDC19 Protein (AA 1-551) (His tag)

Catalog No. ABIN7553177

This Recombinant CCDC19 protein is expressed in HEK-293 Cells.

Quick Overview for CCDC19 Protein (AA 1-551) (His tag) (ABIN7553177)

Target: CCDC19 (Coiled-Coil Domain Containing 19 (CCDC19))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-551

Purification tag / Conjugate: This CCDC19 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant CFAP45 Protein expressed in mammalian cells.

Sequence: MPLSTAGILS SSSAASNRSR NKARYRTKAV SSEVDESLFG DIKSPAQGQS DSPIVLLRDK HTLQKTLTAL GLDRKPETIQ LITRDMVREL IVPTEDPSGE SLIISPEEFE RIKWASHVLT REELEARDQA FKKEKEATMD AVMTRKKIMK QKEMVWNNNK KLSDLEEVAK ERAQNLLQRA NKLRMEQEEE LKDMSKIILN AKCHAIRDAQ ILEKQQIQKE LDTEEKRLDQ MMEVERQKSI QRQEELERKR REERIRGRRQ IVEQMEKNQE ERSLLAEQRE QEKEQMLEYM EQLQEEDLKD MERRQQQKLK MQAEIKRIND ENQKQKAELL AQEKLADQMV MEFTKKKMAR EAEFEAEQER IRREKEKEIA RLRAMQEKAQ DYQAEQDALR AKRNQEVADR EWRRKEKENA RKKMETEAEL RKSRLEQVAF KEHALAVQVQ RDRDEFERIL RAQREQIEKE RLEEEKKATG RLQHANELRR QVRENQQKEV QNRIATFEEG RRLKEEAQKR RERIDEIKRK KLEELRATGL PEKYCIEAER KANILPATSV N Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: CCDC19 (Coiled-Coil Domain Containing 19 (CCDC19))

Alternative Name: CFAP45

Background: Cilia- and flagella-associated protein 45 (Coiled-coil domain-containing protein 19) (Nasopharyngeal epithelium-specific protein 1),FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (PubMed:33139725). {ECO:0000250|UniProtKB:Q32LN4, ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:36191189}.

Molecular Weight: 65.7 kDa

UniProt: Q9UL16

AlphaFold: Q9UL16