STXBP5L Protein (AA 1-1186) (His tag)

Catalog No. ABIN7555620

Product Details

Target: STXBP5L (Syntaxin Binding Protein 5-Like (STXBP5L))

Protein Type: Recombinant

Protein Characteristics: AA 1-1186

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This STXBP5L protein is labelled with His tag.

Purpose: Predefined custom protein recombinant STXBP5L Protein expressed in mammalian cells.

Sequence: MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL INEGALVSAS SDDTLHLWNL RQKRPAILHS LKFNRERITY CHLPFQSKWL YVGTERGNTH IVNIESFILS GYVIMWNKAI ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS KRAELRVYYD EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV LEMDHPIVEF LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE NPYPMDIHES PVTCTAYFAD CPPDLILVLY SIGVKHKKQG YSNKEWPISG GAWNLGAQTY PEIIITGHAD GSIKFWDASA ITLQMLYKLK TSKVFEKQKV GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII YKFSRHEITT EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA YGIVAFGNCN GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ FIADNFCMRG LSNFYPDLTK RIRTSYQSLT ELNDSPVPLE LERCKSPTSD HVNGHCTSPT SQSCSSGKRL SSADVSKVNR WGPGRPPFRK AQSAACMEIS LPVTTEENRE NSYNRSRSSS ISSIDKDSKE AITALYFMDS FARKNDSTIS PCLFVGTSLG MVLIISLNLP LADEQRFTEP VMVLPSGTFL SLKGAVLTFS CMDRMGGLMQ PPYEVWRDPN NIDENEKSWR RKVVMNSSSA SQEIGDHQYT IICSEKQAKV FSLPSQTCLY VHNITETSFI LQANVVVMCS SACLACFCAN GHIMIMSLPS LRPMLDVNYL PLTDMRIART FCFTNEGQAL YLVSPTEIQR LTYSQEMCDN LQDMLGDLFT PIETPEAQNR GFLKGLFGGS GQTFDREELF GEASAGKASR SLAQHIPGPG SIEGMKGAAG GVMGELTRAR IALDERGQRL GELEEKTAGM MTSAEAFSKH AHELMLKYKD KKWYQF Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: STXBP5L (Syntaxin Binding Protein 5-Like (STXBP5L))

Alternative Name: STXBP5L (STXBP5L Products)

Background: Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2),FUNCTION: Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}.

Molecular Weight: 131.9 kDa

UniProt: Q9Y2K9

AlphaFold: Q9Y2K9

Pathways: Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis