JSRP1 Protein (AA 1-332) (His tag)

Catalog No. ABIN7557041

This Recombinant JSRP1 protein is expressed in HEK-293 Cells.

Quick Overview for JSRP1 Protein (AA 1-332) (His tag) (ABIN7557041)

Target: JSRP1 (Junctional Sarcoplasmic Reticulum Protein 1 (JSRP1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-332

Purification tag / Conjugate: This JSRP1 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Jsrp1 Protein expressed in mammalian cells.

Sequence: MTTRGLEDLD GGLGSCLPSD DLPFLEEPAS GRRRESKARG TSRRADSSDW THVLQDPVAA GAGDAGLKKM EKELAGKEST AGKAGTSPRI VPARRKPQAP PPLQPPPPPL QPPPRTPSDD LPWGDLTLNK CLVLASLVAL LGSALQLCRD AVAGEVVAAP HPWVPPSSPP KKEASPAPKP PVLVSPSGSP QPKPGPPQAR MQDEPELPGS PEATETRVER GGSISEASGE ESVPLGDRGS QEKPRKEKPS KGEKLKKEKP RREKPRREDK SQVTGEPRQS LPRRWEAREG GRRPWGRDSR DLLEHGKLQA WAPRRRHDRD DRPRQKRGKG RD Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: JSRP1 (Junctional Sarcoplasmic Reticulum Protein 1 (JSRP1))

Alternative Name: Jsrp1

Background: Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45),FUNCTION: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000250, ECO:0000269|PubMed:16423849, ECO:0000269|PubMed:16638807}.

Molecular Weight: 36.1 kDa

UniProt: Q3MI48

AlphaFold: Q3MI48