Gasdermin C4 Protein (GSDMC4) (AA 1-480) (His tag)

Catalog No. ABIN7557082

This Recombinant Gasdermin C4 protein is produced in HEK-293 Cells.

Quick Overview for Gasdermin C4 Protein (GSDMC4) (AA 1-480) (His tag) (ABIN7557082)

Target: Gasdermin C4 (GSDMC4)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-480

Purification tag / Conjugate: This Gasdermin C4 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Gsdmc4 Protein expressed in mammalian cells.

Sequence: MGYSFDRASK DVVKKLQGRD LRPVECLSDA TKFRLFHILQ ETPRSGWETE DIPVGFTLLD LLEPNFPVPE PEVSAPKPFI HVQSTDLEAN LNVADIARGG VGYVGYGGYN IEVQSTSIPN PKLEILQNRK LLDKLPTFMK FCRMERKNLY VVTEAYEVSK DTMLTGLSSV NLLVKGFFKQ LFKVRGKAGR SEKYSIPIPK GSVLAYKKQQ LVIENNTCVI LPSATKKKMT FPDRPLKLYD LPVTLRYQEE VIETGSWIDD IDPIGTIEEP ANLNFMCLQH EVSEQTQLLA ELSKDVQEVV FSSFLHMLSD RDVLYDLMKM LELNQLGHMD GPGGKILDEL RKDSSTPHDV LKDLNLYLLQ ALLVLSDTQL CLLAQSVKMG LLPHQVELVK SILQTNFKYS SNTPFTLQPQ LLAPLQGEGL AITYELLEEC GLKMELNNPR STWDLEAKMP LSALYGSLSF LQQLQKANSS SKPSLSPGYI Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: Gasdermin C4 (GSDMC4)

Alternative Name: Gsdmc4

Background: Gasdermin-C4 [Cleaved into: Gasdermin-C4, N-terminal (GSDMC4-NT), Gasdermin-C4, C-terminal (GSDMC4-CT)],FUNCTION: [Gasdermin-C4]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C4, N-terminal) binds to membranes and forms pores, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}., FUNCTION: [Gasdermin-C4, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.

Molecular Weight: 54.0 kDa

UniProt: Q3TR54

AlphaFold: Q3TR54