Majin (AA 1-256) protein (His tag)

Catalog No. ABIN7561158

Recombinant Majin protein expressed in HEK-293 Cells.

Quick Overview for Majin (AA 1-256) protein (His tag) (ABIN7561158)

Target: Majin

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-256

Purification tag / Conjugate: His tag

Purpose: Predefined custom protein recombinant Majin Protein expressed in mammalian cells.

Sequence: MSLKPFTYPF PETRFLHAGP NVYKFKIRYG NSIRGEEIED KEVIVQELED SIRAVLANMD SLQPFVTEHF IVFPYKSKWE RVSHLKFKHG ESILTPYPFV FTLYIEMKWF AEDLPSGKPA DDIPLELVLA ETEAEEATMR KWKRKLMEEP SSPSRQGPHR AKMETSSEAS SNKKPLKESK RSTDEEAQQE YQDTPASNAI AVKEQDAALG HGLQGLVVPP LQHSSPPPPK EPGARGFLGF LSALFPFRYF FKKSGQ Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: Majin

Background: Membrane-anchored junction protein,FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000269|PubMed:26548954}.

Molecular Weight: 29.2 kDa

UniProt: Q9D992

AlphaFold: Q9D992