TNFSF14 Protein (AA 1-239) (His tag)

Catalog No. ABIN7561790

Product Details

Target: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Protein Type: Recombinant

Protein Characteristics: AA 1-239

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This TNFSF14 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Tnfsf14 Protein expressed in mammalian cells.

Sequence: MESVVQPSVF VVDGQTDIPF RRLEQNHRRR RCGTVQVSLA LVLLLGAGLA TQGWFLLRLH QRLGDIVAHL PDGGKGSWEK LIQDQRSHQA NPAAHLTGAN ASLIGIGGPL LWETRLGLAF LRGLTYHDGA LVTMEPGYYY VYSKVQLSGV GCPQGLANGL PITHGLYKRT SRYPKELELL VSRRSPCGRA NSSRVWWDSS FLGGVVHLEA GEEVVVRVPG NRLVRPRDGT RSYFGAFMV Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Alternative Name: Tnfsf14 (TNFSF14 Products)

Background: Tumor necrosis factor ligand superfamily member 14 (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form],FUNCTION: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity). {ECO:0000250|UniProtKB:O43557}.

Molecular Weight: 26.3 kDa

UniProt: Q9QYH9

AlphaFold: Q9QYH9

Pathways: Cancer Immune Checkpoints