MGLL Protein (AA 1-303) (His tag)

Catalog No. ABIN7562358

Product Details

Target: MGLL (Monoglyceride Lipase (MGLL))

Protein Type: Recombinant

Protein Characteristics: AA 1-303

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This MGLL protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Mgll Protein expressed in mammalian cells.

Sequence: MPEASSPRRT PQNVPYQDLP HLVNADGQYL FCRYWKPSGT PKALIFVSHG AGEHCGRYDE LAHMLKGLDM LVFAHDHVGH GQSEGERMVV SDFQVFVRDV LQHVDTIQKD YPDVPIFLLG HSMGGAISIL VAAERPTYFS GMVLISPLVL ANPESASTLK VLAAKLLNFV LPNMTLGRID SSVLSRNKSE VDLYNSDPLV CRAGLKVCFG IQLLNAVARV ERAMPRLTLP FLLLQGSADR LCDSKGAYLL MESSRSQDKT LKMYEGAYHV LHRELPEVTN SVLHEVNSWV SHRIAAAGAG CPP Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: MGLL (Monoglyceride Lipase (MGLL))

Alternative Name: Mgll (MGLL Products)

Background: Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL),FUNCTION: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity). {ECO:0000250|UniProtKB:Q99685, ECO:0000269|PubMed:17700715, ECO:0000269|PubMed:18096503, ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20554061, ECO:0000269|PubMed:20729846, ECO:0000269|PubMed:21454566, ECO:0000269|PubMed:9341166}.

Molecular Weight: 33.4 kDa

UniProt: O35678

AlphaFold: O35678

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Lipid Metabolism