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MGLL Products

(Monoglyceride Lipase (MGLL))

Categories

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

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Featured MGLL Categories

MGLL Antibodies

High quality antibodies with extensive validation data.

MGLL ELISA Kits

Reliable ELISA kits for a wide range of species.

MGLL Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MGLL Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (9)
Cat. No. ABIN334436
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (4)
Cat. No. ABIN2855646
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7160192
Quantity 100 μL
Datasheet Datasheet

Recommended MGLL ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968668
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957875
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975648
Quantity 96 tests
Datasheet Datasheet

Recommended MGLL Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1310880
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131650
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2726252
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our MGLL products

Kirkedal, Elfving, Müller, Moreira, Bindila, Lutz, Wegener, Liebenberg: "Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression." in: Neurochemistry international, Vol. 125, pp. 7-15, (2019) (PubMed).

Navia-Paldanius, Patel, López Navarro, Jakupović, Goffart, Pasonen-Seppänen, Nevalainen, Jääskeläinen, Laitinen, Laitinen, Savinainen: "Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11)." in: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 93, pp. 253-63, (2016) (PubMed).

Tang, Wang: "YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation." in: Cellular signalling, Vol. 27, Issue 4, pp. 836-40, (2015) (PubMed).

Iannotti, Silvestri, Mazzarella, Martella, Calvigioni, Piscitelli, Ambrosino, Petrosino, Czifra, Bíró, Harkany, Taglialatela, Di Marzo: "The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 24, pp. E2472-81, (2014) (PubMed).

Laitinen, Navia-Paldanius, Rytilahti, Marjamaa, Kařízková, Parkkari, Pantsar, Poso, Laitinen, Savinainen: "Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 510-9, (2014) (PubMed).

Savinainen, Kansanen, Pantsar, Navia-Paldanius, Parkkari, Lehtonen, Laitinen, Nevalainen, Poso, Levonen, Laitinen: "Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)." in: Molecular pharmacology, Vol. 86, Issue 5, pp. 522-35, (2014) (PubMed).

Navia-Paldanius, Savinainen, Laitinen: "Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)." in: Journal of lipid research, Vol. 53, Issue 11, pp. 2413-24, (2012) (PubMed).

Bolen, Naren, Yarlagadda, Beranova-Giorgianni, Chen, Norman, Baker, Rowland, Best, Sano, Tsukahara, Liliom, Igarashi, Tigyi: "The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation." in: Journal of lipid research, Vol. 52, Issue 5, pp. 958-70, (2011) (PubMed).

Blankman, Simon, Cravatt: "A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol." in: Chemistry & biology, Vol. 14, Issue 12, pp. 1347-56, (2007) (PubMed).

Synonyms and alternative names related to MGLL

monoglyceride lipase (mgll), monoglyceride lipase (MGLL), monoglyceride lipase L homeolog (mgll.L), 13L protein (13L), monoglyceride lipase (YMTVg13L), Monoglyceride lipase (EHI_044210), Monoglyceride lipase (EHI_045330), monoglyceride lipase (TATV_DAH68_039), monoglyceride lipase (13L), monoglyceride lipase (Mgll), AA589436, cb909, hu-k5, HU-K5, HUK5, MAGL, Magl, MGC84195, mgl, MGL, Mgl, MGLL, mgll, wu:fc66g01, zgc:56561

Protein level used designations for MGLL

  • monoglyceride lipase
  • Monoglyceride lipase
  • lysophospholipase homolog
  • monoacylglycerol lipase
  • MGL
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