PLEKHA7 Protein (AA 1-1118) (His tag)

Catalog No. ABIN7563726

Recombinant PLEKHA7 protein expressed in HEK-293 Cells.

Quick Overview for PLEKHA7 Protein (AA 1-1118) (His tag) (ABIN7563726)

Target: PLEKHA7 (Pleckstrin Homology Domain Containing, Family A Member 7 (PLEKHA7))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-1118

Purification tag / Conjugate: This PLEKHA7 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Plekha7 Protein expressed in mammalian cells.

Sequence: MAAAVGRDTL PEHWSYGVCR DGRVFFINDQ LRCTTWLHPR TGEPVNSGHM IRSDLPRGWE EGFTEEGASF FIDHNQQTTT FRHPVTGQFS SENSEYVLRE EPHPHMSKPE RNQRPSSMVS ETSTAGTTST LEAKPGPKIV KSSSKVHSFG KRDQAIRRNL NVPVVVRGWL HKQDSSGMRL WKRRWFVLAD YCLFYYKDSR EEAVLGSIPL PSYVISPVAP EDRISRKYSF KAVHTGMRAL IYSTTTAGSQ MEHSGMRTYY FSADTLEDMN AWVRAMNQAA QVLSRSSLRR DVDKVERQAM PQANHTDACQ ECGHVGPGHS RDCPRRGYED SYGFNRREQE EERFRAQRDP LEGRRDRSKA RSPYLPAEED ALFVDLPGGP RGQQAQPQRA EKNGVPPYGL GEQNGTNGYQ RTAPPRANPE KHSQRKTGLA QAEHWTKAQK GDGRSLPLDQ TLPRQGPSQP LSFPENYQSL PKSTRHLSGS SSPPPRNLPS DYKYAQDRAS HLKMSSEERR AHRDGTVWQL YEWQQRQQFR HGSPTAPIGA GSPEFTEQGR SRSLLEVPRS ISVPPSPSDI PPPGPPRPFP PRRPHTPAER VTVKPPEQRR SVDISLGGSP RKARGHAAKN SSHVDRRSMP SMGYMTHTVS APSLHGKSAD DTYLQLKKDL EYLDLKMTGR DLLKDRSLKP MKIAESDIDV KLSIFCEQDR ILQDLEDKIR ALKENKDQLE SVLEVLHRQT EQYRDQPQHL EKITCQQRLL QEDLVHIRAE LCRESTEMEN AWNEYLKLEK DVEQLKQTLQ EQHRRAFFFQ EKSQIQKDLW RIEDVMAGLS ANKENYRVLV GSVKNPERKT VPLFPHPSVP SLSPTESKPA LQPSPPTSPV RTPLEVRLFP QLQTYVPYRP HPPQLRKVMS PLQSPTKAKP QAEDEAPPRP PLPELYSPED QPPAVPPLPR EATIIRHTSV RGLKRQSDER KRDREQGQCV NGDLKVELRS YVSEPELASL SGDVPQPSLS LVGSESRYQT LPGRGLSGST SRLQQSSTIA PYVTLRRGLN AENSSATFSR PKSALERLYS GDHQRGKMSA EEQLERMKRH QKALVRERKR TLSQGEKTGL LSARYLSQPL PGDLGSVC Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PLEKHA7 (Pleckstrin Homology Domain Containing, Family A Member 7 (PLEKHA7))

Alternative Name: Plekha7

Background: Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) (Heart adapter protein 1),FUNCTION: Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000250|UniProtKB:Q6IQ23, ECO:0000269|PubMed:30463011}.

Molecular Weight: 126.7 kDa

UniProt: Q3UIL6

AlphaFold: Q3UIL6

Pathways: Cell-Cell Junction Organization