STXBP5L Protein (AA 1-1185) (His tag)

Catalog No. ABIN7563799

Product Details

Target: STXBP5L (Syntaxin Binding Protein 5-Like (STXBP5L))

Protein Type: Recombinant

Protein Characteristics: AA 1-1185

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This STXBP5L protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Stxbp5l Protein expressed in mammalian cells.

Sequence: MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IADNFCMRGL SNFYPDLTKR IRTSYQSLTE LNDSPVPLEL ERCKSPTSDH VNGHCTSPTS QSCSSGKRLS SADVSKVNRW GPGRPPFRKA QSAACMEISL PVTTEETREN SYNRSRSSSI SSIDKDSKEA ITALYFMESF ARKNDSTVSP CLFVGTSLGM VVLISLNLPS SDEQRFTEPV VVLPSGTFLS LKGAVLTFSC MDRTGSLMQP PYEVWRDPNN TDENEKTWKR KLVMNYSSSS QEMGDHQYTI ICSEKQAKVF SLPSQTCLYV HNITETSFIL QADVVVMCNS ACLACFCANG HIMIMSLPSL RPMLDVNYLP LTDMRIARTF CFTNEGQALY LVSPTEIQRL TYSQEMCDNI QDMLGDLFTP IETPEAQNRG FLKGLFGGSG QTFDREELFG EASAGKASRS LAQHIPGPGS IEGMKGAAGG VMGELTRARI ALDERGQRLG ELEEKTAGMM TSAEAFSKHA HELMLKYKDK KWYQF Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: STXBP5L (Syntaxin Binding Protein 5-Like (STXBP5L))

Alternative Name: Stxbp5l (STXBP5L Products)

Background: Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2),FUNCTION: Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9Y2K9, ECO:0000269|PubMed:21998599, ECO:0000269|PubMed:24744148, ECO:0000269|PubMed:25002582}.

Molecular Weight: 131.8 kDa

UniProt: Q5DQR4

AlphaFold: Q5DQR4

Pathways: Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis