ARHGAP24 Protein (AA 1-747) (His tag)

Catalog No. ABIN7564514

Product Details

Target: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Protein Type: Recombinant

Protein Characteristics: AA 1-747

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ARHGAP24 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Arhgap24 Protein expressed in mammalian cells.

Sequence: MEERCESTES PQGQGRKNTK CGWLRKQGGF VKTWHTRWFV LKGDQLYYFK DEDETKPLGT IFLHGNKVIE HPCNEENPGK FLFDVVPGGE RDRMTANHES YLLMASTQND MEDWVKSIRR VIWGPFGGGI FGQKLEDTVR YEKRYGNRLA PMLVEQCVDF IRQRGLKEEG LFRLPGQANL VKELQDAFDC GEKPSFDSNT DVHTVASLLK LYLRELPEPV VPYAKYEDFL SCATLLSKEE EAGVKELMKQ VKSLPVVNYN LLKYICRFLD EVQSYSGVNK MSAQNLATVF GPNILRPKVE DPLTIMEGTV VVQQLMSVMI SKHDRLFPKD TEPQSKPQDG PNSNNNDGHK KATMGQLQNK ENNNTKESPV RRCSWDKPES PQRSSVDNGS PTALSGSKTN SPRNSIHKLD ISRSPPLMVK KNPAFNKGSG IVTNGSFSSS NAEGVEKPQT TPNGSLQARR TSSLKSSGTK MGTHSVQNGT VRMGILNTDT LGNSLNGRSM SWLPNGYVTL RDNKQKEPAG ESGQHNRLST YDNVHQQFSS MSLDDKHSVD SATWSTSSCE ISLPENSNSC RSSTTTCPEQ DFYVGNFEDP VLDGPPQDDL SHPGDYENKS DRRSVGGRSS RATSSSDNSE TFVGNTSSNH SALHSLVSSL KQEMTKQKIE YESRIKSLEQ RNLTLETEML SLHDELDQER KKFTMIEIKM RNAERAKEDA EKRNDMLQKE MEQFFSTFGD LTVEPRRSER GNTIWIQ Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Alternative Name: Arhgap24 (ARHGAP24 Products)

Background: Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24),FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity). {ECO:0000250}.

Molecular Weight: 84.1 kDa

UniProt: Q8C4V1

AlphaFold: Q8C4V1

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus