MYO3A Protein (AA 1-1613) (His tag)

Catalog No. ABIN7564652

Product Details

Target: MYO3A (Myosin IIIA (MYO3A))

Protein Type: Recombinant

Protein Characteristics: AA 1-1613

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This MYO3A protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Myo3a Protein expressed in mammalian cells.

Sequence: MLPLIGKTII FDNFPDPSDT WEIIETIGKG TYGKVFKVLN KKSGQKAAVK ILDPIHDIDE EIEAEYNILR TLSDHPNVVR FYGIYFKKDK INGDKLWLVL ELCNGGSVTD LVKGFLKRGE RMSEPVIAYI LHEALMGLQH LHSNKTIHRD VKGNNILLTT EGGVKLVDFG VSAQLSSTRH RLNTSVGTPF WMAPEVIACE QQLDTTYDAR CDTWSLGITA IELGDGDPPL AELHPMRALF KIPRNPPPKL RQPELWSAEF NDFISKCLTK DYEKRPTVSD LLKHKFITQI EGKDVILQKQ LMEFIDIHQC LGSTEKARHE RIHTKKGNLN RSLISSLKDV DDLATLDVLD EPTASPHLHP CHSRDQIHIH VADILIALNP FQSLGIYSPK LSRLYIGAKR TANPPHIFAM ADLGYQSMVT YNADQCIVIS GESGAGKTES AHLLVQQLTV LGKANNRTLQ EKILQMNNLV EAFGNACTII NDNSSRFGKY LEMKFTSSGA VVGAQISEYL LEKSRVIHQA MGEKNFHIFY YIYGGLAEKK KLALYKSPEH KPPRYLQNDN LRTVQDMMNN SFYKSQYELI EQCFKVIGFT MEQLASVYSV LAAILNVGNI EFSSVATEYQ MDKSYICNHT ALENCASLLC IQADELQEAL TSHCVVTRGE TIIRPNTVEK AADVRDAMAK TLYGRLFSCI VNCINSLLKH DTSPSGDEEL NIGILDIFGF ENFKRNSFEQ LCINIANEQI QYYFNQHVFA WEQNEYLNED VDARVIEYED NRPLLDMFLQ KPMGLLSLLD EESRFPKATD QTLIEKFEDN LKSQYFWRPK RMELSFGIHH YAGKVLYSAS GFLAKNRDTF PTDIVLPLRS SENSVIRQLV NHPLTKTGNL PLSKTKNIVN YQMWNSEKST NLTKGETRDV TCHACETTNV KTQTVSSYFR YSLMDLLSKM VVGQPHFVRC IKPNNERQAR KYDKEKVLLQ LRCTGILETA RIRRLGYSHR ILFANFIKRY YILCYKSSEE PPVSPDTCAA ILEKAGLDNW ALGKTKVFLK YYHVEQLNLM RKEATNKLVL IQASVRAFLG ARRYQELQQK RKSSAVIIQS AARGHLVRKQ RKEIVDMKNT AVTTIQTSDQ EFDYKKNFEN TRESFVKKQT ENAVPTNESN TSTPNNKESP SAGKTAPFIA ESKATNVESN NRRYHTQKKM SNVYAEGQNQ ELYIVEDTWA EVSPRQKYVQ DLEESRKMRK EEKGDAVIQS YCQWYTEGSN FEESKATCLE GRETWERTSC PGLWLTEEIY LRKTLDPTLS QKSVYQNADG KEKEHKVSVV TQNAPLGNLE RDYHLLGFLG EEDTGPVPQA QEEHKAVSIH SKYQSSKKKQ QLGKDRLAPP FKNQKILSSS TEVAKTTHNV YPCPTKQEGV HHSKMVDERD SKMASKKEAW DLAMFSRQIS KLSEEYFILQ KNLNEIILAQ QLKPFYLGIY RHKPINRHVS THQYLSGVSK GEEPKILRPP RRPRKPKTLN NPEDSTYYYL LHKSTQEEKR RPGKDSQGKL LGLEDFYYKE FLPTHYGPKA HSSNAREWKA LKEPQAQPIE SNERCWTTSE NESLEEERIS ANPYDYRRLL RKTSQRQRLV QQL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: MYO3A (Myosin IIIA (MYO3A))

Alternative Name: Myo3a (MYO3A Products)

Background: Myosin-IIIa (EC 2.7.11.1),FUNCTION: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:19287378). {ECO:0000250|UniProtKB:Q8NEV4, ECO:0000269|PubMed:19287378, ECO:0000269|PubMed:26754646}.

Molecular Weight: 184.7 kDa

UniProt: Q8K3H5

AlphaFold: Q8K3H5

Pathways: Sensory Perception of Sound, Phototransduction