LTBR Protein (AA 31-225) (Fc Tag)
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- Target See all LTBR Proteins
- LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 31-225
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Origin
- Human
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Source
- CHO Cells
- Purification tag / Conjugate
- This LTBR protein is labelled with Fc Tag.
- Purpose
- LTbetaR (human):Fc (human) (rec.) (non-lytic)
- Cross-Reactivity
- Human
- Characteristics
- The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1.
- Purity
- >98 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
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Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-227) protein (Fc Tag)
LTBR Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-223) protein (Fc Tag)LTBR Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 28-227) protein (His tag)LTBR Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90% by SDS-PAGE SDS
Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-435) protein (GST tag)LTBR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) protein (Fc Tag)LTBR Origin: Rat Host: HEK-293 Cells Recombinant (9.8+79.7) % as determined by SDS-PAGE
Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) protein (His tag)LTBR Origin: Rat Host: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))
- Alternative Name
- LTbetaR (LTBR Products)
- Background
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Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
- NCBI Accession
- NP_002333
- Pathways
- NF-kappaB Signaling
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