TIMD4 Protein (AA 22-279) (Fc Tag)

Catalog No. ABIN7566382

Recombinant TIMD4 protein expressed in CHO Cells.

Quick Overview for TIMD4 Protein (AA 22-279) (Fc Tag) (ABIN7566382)

Target: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: CHO Cells

Purity: >95 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 22-279

Purification tag / Conjugate: This TIMD4 protein is labelled with Fc Tag.

Purpose: Tim-4 (mouse):Fc (human) (rec.)

Cross-Reactivity: Mouse

Characteristics: The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1.

Sterility: Sterile filtered

Endotoxin Level: <1EU/mg protein (LAL test, Lonza).

Biological Activity Comment: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Alternative Name: Tim-4

Background:

TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4

Mouse T cell immunoglobulin and mucin domain-containing protein 4, also known as T cell membrane protein 4, TIMD4 and TIM4 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells and may also be involved in intercellular signaling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.

Molecular Weight: ~70-85kDa (SDS-PAGE, reducing conditions)

NCBI Accession: NP_848874

Pathways: Cancer Immune Checkpoints