TIMD4 Protein (AA 23-279) (Fc Tag)

Catalog No. ABIN7566383

This Recombinant TIMD4 protein is produced in HEK-293 Cells.

Quick Overview for TIMD4 Protein (AA 23-279) (Fc Tag) (ABIN7566383)

Target: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human, Mouse

Source: HEK-293 Cells

Purity: >95 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 23-279

Purification tag / Conjugate: This TIMD4 protein is labelled with Fc Tag.

Purpose: Tim-4 (mouse):Fc (human) (rec.)

Cross-Reactivity: Human, Mouse

Characteristics: The extracellular domain of mouse Tim-4 (aa 23-279) is fused to the N-terminus of the Fc region of human IgG1.

Endotoxin Level: <0.01EU/μg purified protein (LAL test).

Biological Activity Comment: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 1 mg/mL after reconstitution

Concentration: 1 mg/mL

Buffer: Contains PBS.

Handling Advice: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Alternative Name: Tim-4

Background:

TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4

Tim-4 (T cell immunoglobulin and mucin domain-containing protein 4) is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. Tim-4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 is expressed solely on antigen presenting cells (APCs) and is not found on T cells in contrast to TIM1 and TIM3. Tim-4 has a short intracellular domain and lacks an inward signaling motif. Tim-4 plays an important role in the proliferation of T helper type 2 (Th2) cells. Tim-4 binds to phosphatidylserine (PS) on the surface of apoptotic cells in a calcium-dependent manner and mediates phagocytosis of apoptotic cells.

Molecular Weight: ~110kDa (SDS-PAGE)

UniProt: Q6U7R4

Pathways: Cancer Immune Checkpoints