CD40 Protein (CD40) (AA 21-193) (hIgG-His-tag)
Quick Overview for CD40 Protein (CD40) (AA 21-193) (hIgG-His-tag) (ABIN7596337)
Target
See all CD40 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 21-193
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Purification tag / Conjugate
- This CD40 protein is labelled with hIgG-His-tag.
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Sequence
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EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR
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Endotoxin Level
- < 1 EU per 1ug of protein (determined by LAL method)
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CD40 (CD40) (AA 21-193) protein (His-Avi Tag,Biotin)
CD40 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD40 (CD40) (AA 21-193) protein (His tag)CD40 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD40 (CD40) (AA 24-193) protein (His tag)CD40 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD40 (CD40) (AA 21-193) protein (Fc Tag)CD40 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD40 (CD40) (AA 21-193) protein (His tag)CD40 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD40 (CD40) (AA 21-193) protein (mFc-His Tag)CD40 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD40 (CD40) (AA 21-193) protein (His-DYKDDDDK-Strep II Tag)CD40 Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD40 (CD40) (AA 24-193) (Active) protein (His tag)CD40 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD40 (CD40) (AA 21-193) (Active) protein (His tag)CD40 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD40 (CD40) (AA 21-193) (Active) protein (His tag)CD40 Origin: Cynomolgus Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
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- CD40
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Alternative Name
- CD40/TNFRSF5
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Background
- CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily. It transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglubiln secretion. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 Molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. Recombinant human CD40, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
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Molecular Weight
- 46.1kDa (412aa)
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NCBI Accession
- NP_001241
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Pathways
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
Target
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