TSH receptor Protein (DYKDDDDK Tag,Strep Tag)
Quick Overview for TSH receptor Protein (DYKDDDDK Tag,Strep Tag) (ABIN7596530)
Target
See all TSH receptor (TSHR) ProteinsProtein Type
Origin
Source
Application
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Purification tag / Conjugate
- This TSH receptor protein is labelled with DYKDDDDK Tag,Strep Tag.
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Purpose
- Human TSHR-Strep full length protein-synthetic nanodisc
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Thyroid Stimulating Hormone Receptor (TSHR) protein
TSHR Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Thyroid Stimulating Hormone Receptor (TSHR) (AA 22-260) protein (His tag)TSHR Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Thyroid Stimulating Hormone Receptor (TSHR) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)TSHR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Comment
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Advantages:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Mammalian cell expression system ensures post- translational modifications
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
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Alternative Name
- TSHR
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Background
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CHNG1, hTSHR-I, LGR3
The protein is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. -
Molecular Weight
- The human full length TSHR-Strep protein has a MW of 86.8 kDa
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UniProt
- P16473
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Pathways
- Thyroid Hormone Synthesis
Target
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