GPBAR1 Protein (DYKDDDDK Tag,Strep Tag)
Quick Overview for GPBAR1 Protein (DYKDDDDK Tag,Strep Tag) (ABIN7596763)
Target
See all GPBAR1 ProteinsProtein Type
Origin
Source
Application
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Purification tag / Conjugate
- This GPBAR1 protein is labelled with DYKDDDDK Tag,Strep Tag.
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Purpose
- Human GPBAR1-Strep full length protein-synthetic nanodisc
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G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (AA 1-329) protein (His tag)
custom-made GPBAR1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (AA 1-330) protein (His tag)custom-made GPBAR1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (AA 1-330) protein (GST tag)GPBAR1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
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Comment
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Advantages:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Mammalian cell expression system ensures post- translational modifications
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
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Alternative Name
- GPBAR1
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Background
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BG37, GPCR19, GPR131, M-BAR, TGR5
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] -
Molecular Weight
- The human full length GPBAR-Strep protein has a MW of 35.2 kDa
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UniProt
- Q8TDU6
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Pathways
- WNT Signaling, Hormone Transport, Sensory Perception of Sound
Target
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