TSH receptor Protein (AA 99-330) (Fc Tag)

Catalog No. ABIN7597440

Recombinant TSH receptor protein expressed in HEK-293 Cells.

Quick Overview for TSH receptor Protein (AA 99-330) (Fc Tag) (ABIN7597440)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 99-330

Purification tag / Conjugate: This TSH receptor protein is labelled with Fc Tag.

Purpose: Recombinant human TSHR(23-410) Protein with N-terminal human Fc tag

Sequence: hFc(Glu99-Ala330) TSHR(Gly23-Asp410)

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Alternative Name: TSHR

Background: LGR3, CHNG1, hTSHR-I
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Molecular Weight: predicted molecular mass of 70.3 kDa after removal of the signal peptide. The apparent molecular mass of hFc-TSHR(23-410) is 70-130 kDa due to glycosylation.

UniProt: P16473

Pathways: Thyroid Hormone Synthesis