Neuregulin 1 Protein (NRG1) (AA 20-241) (His tag)

Catalog No. ABIN7607517

Recombinant Neuregulin 1 protein expressed in Mammalian Cells.

Quick Overview for Neuregulin 1 Protein (NRG1) (AA 20-241) (His tag) (ABIN7607517)

Target: Neuregulin 1 (NRG1)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Mammalian Cells

Application: Western Blotting (WB), SDS-PAGE (SDS), Immunogen (Imm), ELISA, Activity Assay (AcA)

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 20-241

Purification tag / Conjugate: This Neuregulin 1 protein is labelled with His tag.

Purpose: Recombinant Human NRG1/Neuregulin-1 Protein, C-His (Active)

Endotoxin Level: <0.1 EU/μg of the protein by the LAL method.

Biological Activity Comment: Measured in a serum-free cell proliferation assay using human breast cancer cells (MCF-7). The ED50 for this effect is 20-100 ng/mL.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a solution in PBS pH 7.4, 5 % Trehalose, 5 % Mannitol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Expiry Date: 12 months

Target Details

Target: Neuregulin 1 (NRG1)

Alternative Name: Glial growth factor

Background: Glial growth factor, Neu differentiation factor, SMDF, Breast cancer cell differentiation factor p45, Pro-neuregulin-1, membrane-bound isoform, Acetylcholine receptor-inducing activity, ARIA, GGF, HRGA, Pro-NRG1, HGL, HRG, NDF, NRG1, Sensory and motor neuron-derived factor, Heregulin

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation