ACSL4 Protein (AA 184-277) (SUMO Tag)

Catalog No. ABIN7668111

Recombinant ACSL4 protein expressed in Escherichia coli (E. coli).

Quick Overview for ACSL4 Protein (AA 184-277) (SUMO Tag) (ABIN7668111)

Target: ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))

Protein Type: Recombinant

Biological Activity: Inactive

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 90 %

Product Details

Protein Characteristics: AA 184-277

Purification tag / Conjugate: This ACSL4 protein is labelled with SUMO Tag.

Purpose: Recombinant Human ACSL4 Protein(Sumo Tag)

Sequence: Leu184-Tyr277

Purification: SDS-PAGE analysis of Human ACSL4 proteins, 2μg/lane of Recombinant Human ACSL4 proteins was resolved with SDS-PAGE under reducing conditions, showing bands at 30 KD

Sterility: 0.2 μm filtered

Endotoxin Level: < 10 EU/mg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))

Alternative Name: ACSL4

Background: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis.,ACS,ACSL,FACL,LACS,MRX,ACSL4,ACS4,FACL4,LACS4,MRX63,MRX68,ACS 4,ACSL 4,acyl CoA synthetase 4,Acyl CoA synthetase long chain family member 4,FACL 4,Fatty acid Coenzyme A ligase,fatty acid Coenzyme A ligase long-chain 4,LACS 4,Lignoceroyl CoA synthase,Long chain 4,long chain acyl CoA synthetase 4,long chain fatty acid CoA ligase 4,long chain fatty acid Coenzyme A ligase 4,Long-chain acyl-CoA synthetase 4,Long-chain-fatty-acid--CoA ligase 4

Molecular Weight:

calculated_mw: 26.3 kDa

observed_mw: 30 kDa

UniProt: O60488