Ataxin 2 Protein (ATXN2) (GST tag)

Catalog No. ABIN7668199

This Recombinant Ataxin 2 protein is produced in Escherichia coli (E. coli).

Quick Overview for Ataxin 2 Protein (ATXN2) (GST tag) (ABIN7668199)

Target: Ataxin 2 (ATXN2)

Protein Type: Recombinant

Biological Activity: Inactive

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 %

Product Details

Purification tag / Conjugate: This Ataxin 2 protein is labelled with GST tag.

Purpose: Recombinant Human ATXN2 protein (GST tag)

Sequence: Leu 460-Ser 600

Purification: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: < 10 EU/mg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Ataxin 2 (ATXN2)

Alternative Name: ATXN2

Background: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.,ATX2,ATXN2,Ataxin-2,SCA2,Spinocerebellar ataxia type 2 protein,TNRC13,Trinucleotide repeat-containing gene 13 protein

Molecular Weight:

calculated_mw: 40.4 kDa

observed_mw: 42 kDa

UniProt: Q99700

Pathways: Ribonucleoprotein Complex Subunit Organization