CBLC Protein (His-GST)

Catalog No. ABIN7668326

This Recombinant CBLC protein is expressed in Baculovirus infected Insect Cells.

Quick Overview for CBLC Protein (His-GST) (ABIN7668326)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Protein Type: Recombinant

Biological Activity: Inactive

Origin: Human

Source: Baculovirus infected Insect Cells

Purity: > 95 %

Product Details

Purification tag / Conjugate: This CBLC protein is labelled with His-GST.

Purpose: Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag)

Sequence: Met 1-Ala474

Purification: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM Nacl, 10 % glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CBLC (Cbl proto-oncogene C (CBLC))

Alternative Name: Cbl-c

Background: CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c gene.,CBL-3,CBL-SL,RNF57

Molecular Weight:

calculated_mw: 80.2 kDa

observed_mw: 66 kDa

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway