OPTN Protein (His tag)
Quick Overview for OPTN Protein (His tag) (ABIN7669392)
Target
See all OPTN ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This OPTN protein is labelled with His tag.
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Purpose
- Recombinant Human OPTN protein (His tag)
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Sequence
- Met1-353Glu
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Purification
- > 95 % as determined by reducing SDS-PAGE.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 10 EU/mg of the protein as determined by the LAL method.
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Optineurin (OPTN) (AA 1-584) protein (His tag)
custom-made OPTN Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Optineurin (OPTN) (AA 1-577) protein (His tag)custom-made OPTN Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Optineurin (OPTN) (AA 16-223) protein (His-IF2DI Tag)OPTN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Optineurin (OPTN) (AA 1-577) protein (GST tag)OPTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Optineurin (OPTN) (AA 1-571) protein (GST tag)OPTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- OPTN (Optineurin (OPTN))
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Alternative Name
- OPTN
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Background
- Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.,OPTN,Optineurin
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Molecular Weight
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calculated_mw: 38.7 kDa
observed_mw: 45 kDa
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UniProt
- Q96CV9
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Pathways
- M Phase
Target
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