CD4 Protein (CD4) (His tag)
Quick Overview for CD4 Protein (CD4) (His tag) (ABIN7794645)
Target
See all CD4 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This CD4 protein is labelled with His tag.
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Purpose
- Recombinant human CD4 Protein with C-terminal 6?His tag
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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- CD4
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Alternative Name
- CD4
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Background
- T4, IMD79, Leu-3, OKT4D, CD4mut Background: This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
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Molecular Weight
- Predicted: 42.1 kDa after removal of the signal peptide. The apparent molecular mass of CD4-His is approximately 35-55 kDa due to glycosylation.
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UniProt
- P01730
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Pathways
- TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
Target
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