alpha-Thrombin Protein

Catalog No. ABIN934838

This Native alpha-Thrombin protein is produced in Human. There are 3 publications available.

Quick Overview for alpha-Thrombin Protein (ABIN934838)

Target: alpha-Thrombin

Protein Type: Native

Biological Activity: Active

Origin: Human

Source: Human

Purity: > 95 % pure

Product Details

Characteristics: Purified native Human alpha Thrombin protein
Bioactivity: 4493 units/mg protein- Specific activity is determined by fibrinogen clotting assay relative to human NIH standard thrombin.
Protein Source: Human serum/plasma

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a liquid with 50 % Glycerol/H2 O (vol/vol).

Precaution of Use: Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C.

References

Steinert, Berg, Kalinin, Jagels, Würthwein, Humpf, Kalinina: "Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum." in: ACS omega, Vol. 7, Issue 49, pp. 45215-45230, (2022) (PubMed).

Dunker, Imberg, Siutkina, Erbacher, Daniliuc, Karst, Kalinin: "Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity." in: Pharmaceuticals (Basel, Switzerland), Vol. 15, Issue 11, (2022) (PubMed).

Platte, Korff, Imberg, Balicioglu, Erbacher, Will, Daniliuc, Karst, Kalinin: "Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors." in: ChemMedChem, Vol. 16, Issue 24, pp. 3672-3690, (2022) (PubMed).

Target Details

Target: alpha-Thrombin

Alternative Name: alpha Thrombin

Background: Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII.
Description: Human serum/plasma.
Alternative Names: Thrombin alpha protein

Molecular Weight: 36.7 kDa