TPMT Protein (AA 1-245)
Quick Overview for TPMT Protein (AA 1-245) (ABIN934951)
Target
See all TPMT ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-245
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Sequence
- MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK
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Characteristics
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Purified recombinant Human TPMT protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.
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Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (His tag)
custom-made TPMT Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Thiopurine S-Methyltransferase (TPMT) (AA 1-240) protein (His tag)custom-made TPMT Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (GST tag)TPMT Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Thiopurine S-Methyltransferase (TPMT) (AA 4-244), (partial) protein (GST tag)TPMT Origin: Human Host: Escherichia coli (E. coli) Recombinant 95 % ELISA
Thiopurine S-Methyltransferase (TPMT) protein (Myc-DYKDDDDK Tag)TPMT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- TPMT protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Supplied as a liquid in 20 mM Tris, pH 8.0, containing 0.0 mM PMSF, and 0 mM EDTA.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- TPMT (Thiopurine S-Methyltransferase (TPMT))
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Alternative Name
- TPMT
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Background
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TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity. Recombinant human TPMT was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: Thiopurine methyltransferase protein, Thiopurine S methyltransferase., Thiopurine S-methyltransferase HGNC:12014 protein, Thiopurine S-methyltransferase protein, TPMT protein, S adenosyl L methionine thiopurine S methyltransferase protein -
Molecular Weight
- 28 kDa (245 AA)
Target
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