PSMD10 Protein (AA 1-226)
Quick Overview for PSMD10 Protein (AA 1-226) (ABIN934994)
Target
See all PSMD10 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-226
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Sequence
- MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
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Characteristics
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Purified recombinant Human Gankyrin protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.
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Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-226) protein (His tag)
custom-made PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-231) protein (His tag)custom-made PSMD10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-226) protein (GST tag)PSMD10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 1) proteinPSMD10 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Gankyrin protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Supplied as a liquid in PBS, pH 7.4, containing 10 % glycerol.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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Alternative Name
- Gankyrin
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Background
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Gankyrin is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome. It is known to play a role in the regulation of the phosphorylation of the retinoblastoma protein by CDK4, and to enhance the ubiquitinylation of p53 by MDM2. Gankyrin consists of 7 ankyrin repeats and is structurally similar to I kappa Bs. Recombinant human Gankyrin was expressed in E. coli and purified by conventional chromatography techniques.
Alternative Names: Gankyrin protein, 26S proteasome regulatory subunit p28 protein, 26S proteasome non-ATPase regulatory subunit 10 protein, PSMD10., proteasome 26S subunit non ATPase 10 (PSMD10) isoform 1 protein, ankyrin repeat protein p28 protein -
Molecular Weight
- 24.4 kDa (226 AA)
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Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
Target
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