HIF1AN Protein (AA 1-349)

Catalog No. ABIN935007

This Recombinant HIF1AN protein is expressed in Escherichia coli (E. coli).

Quick Overview for HIF1AN Protein (AA 1-349) (ABIN935007)

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 90 % pure

Product Details

Protein Characteristics: AA 1-349

Sequence: MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN

Characteristics: Purified recombinant Human HIF1 AN protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Application Details

Application Notes: HIF1AN protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Storage Comment: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Target Details

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Alternative Name: HIF1AN

Background: Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is a protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes. Recombinant human HIF1AN protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: HIFAN 1, FIH 1 protein, DKFZp762F1811 protein, Hypoxia-inducible factor 1 protein, HIFAN-1, Hypoxia-inducible factor asparagine hydroxylase protein, Hypoxia inducible factor 1 alpha subunit inhibitor protein, alpha subunit inhibitor Hypoxia inducible factor asparagine hydroxylase protein, Factor inhibiting HIF1 protein, Peptide aspartate beta dioxygenase protein, HIFAN-1 protein, HIFAN 1 protein, FLJ22027 protein, FLJ20615 protein, Hypoxia inducible factor 1 alpha inhibitor protein, FIH1 protein, Factor inhibiting HIF-1 protein, Hypoxia-Inducible Factor-1 Alpha Inhibitor, HIF1AN

Molecular Weight: 40.2 kDa (349 AA)

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development