Cytokeratin 18 Protein
Quick Overview for Cytokeratin 18 Protein (ABIN935173)
Target
See all Cytokeratin 18 (KRT18) ProteinsProtein Type
Origin
Source
Purity
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Characteristics
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Purified recombinant Human Cytokeratin 18 protein
Expression System: E.coli
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Keratin 18 (KRT18) (AA 1-430) protein (His tag)
KRT18 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Keratin 18 (KRT18) (AA 1-430) protein (GST tag)KRT18 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- 1 mg/mL
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Buffer
- Supplied in lyophilized form with 30 mM Tris/HCI pH 8, 9.5 M urea, 2 mM DTT, 2 mM EDTA, 10 mM methylammonium chloride.
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Preservative
- Dithiothreitol (DTT)
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Precaution of Use
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 2-8 °C in lyophilized form. Following reconstitution aliquot and store at -20 °C for long term storage.
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- Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))
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Alternative Name
- Keratin K18
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Background
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Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
Alternative Names: Keratin K18, Keratin K-18, Cytokeratin 18 protein, Keratin K 18, Keratin K-18 protein, Keratin 18 protein, Keratin K 18 protein -
Molecular Weight
- 45 kDa
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Pathways
- Apoptosis, Caspase Cascade in Apoptosis
Target
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