WISP2 Protein

Catalog No. ABIN935289

This Recombinant WISP2 protein is expressed in Escherichia coli (E. coli).

Quick Overview for WISP2 Protein (ABIN935289)

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % pure

Product Details

Sequence: MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF

Characteristics: Purified recombinant Human CTGFL protein
Expression System: E.coli
Bioactivity: The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is between 10-20 ng/mL in the presence of 15 ng/mL of human IGF-II.

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in water to a concentration of 0.1- 1.0 mg/mL. Do not raise to neutral pH.

Buffer: Supplied lyophilized with no additives.

Preservative: Without preservative

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Target Details

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Alternative Name: CTGFL

Background: CTGFL/WISP-2 is a 24.3 kDa protein that belongs to the CCN family of cysteine rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors.
Alternative Names: WISP2 protein, CCN5 protein, CT-58 protein, Connective Tissue Growth Factor-Like protein protein

Molecular Weight: 24.3 kDa

Pathways: WNT Signaling, Growth Factor Binding