FGF acidic (Active) Protein
This Recombinant protein is expressed in Escherichia coli (E. coli).
Catalog No. ABIN935373
Quick Overview for FGF acidic (Active) Protein (ABIN935373)
Target
FGF acidic
Protein Type
Recombinant
Biological Activity
Active
Origin
Human
Source
Escherichia coli (E. coli)
Purity
> 95 % pure
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Sequence
- MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
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Characteristics
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Purified recombinant Human FGF acidic protein
Expression System: E.coli
Bioactivity: Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by 3T3 cells in the presence of heparin is ? 0.5 ng/mL corresponding to a specific activity of ? 2 x 10^6 units/mg. Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ? 0.2 ng/mL in the presence of 10 µg/mL heparin, corresponding to a specific activity of ? 5 x 10^6 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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FGF acidic (AA 16-155) protein
Origin: Human Host: Escherichia coli (E. coli) Recombinant >98 % as determined by SDS-PAGE.
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- FGF acidic
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Background
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FGF acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF acidic has the ability to signal through all the FGF receptors.
Alternative Names: FGF-1 protein, ECGF-beta protein, HBGF-1 protein, Fibroblast Growth Factor-acidic protein -
Molecular Weight
- 15.9 kDa
Target
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