IL-17 Protein

Catalog No. ABIN935482

Recombinant IL-17 protein expressed in Escherichia coli (E. coli).

Quick Overview for IL-17 Protein (ABIN935482)

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 98 % pure

Product Details

Sequence: MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA

Characteristics: Purified recombinant Human IL17 protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/mL. Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Keep pH below 5.0.

Buffer: Supplied lyophilized with no additives.

Preservative: Without preservative

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Target Details

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Alternative Name: IL17

Background: The originally described IL17 protein, now known as IL17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL17A through IL17F, are secreted as homodimers. IL17A exhibits cross-species bioactivity between human and Mouse cells.
Alternative Names: IL-17, Interleukin 17 protein, IL-17 protein, IL17, IL 17, CTLA-8 protein, IL-17 protein, IL 17 protein

Molecular Weight: 31 kDa