IL1A Protein
Quick Overview for IL1A Protein (ABIN935485)
Target
See all IL1A ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
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Characteristics
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Purified recombinant Human IL1 alpha protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of Mouse D10S cells is ? 0.001 ng/mL, corresponding to a specific activity of ? 1 x 10^9 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Interleukin 1 alpha (IL1A) (Active) protein
IL1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 1 alpha (IL1A) (AA 113-271) protein (His tag)IL1A Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 1 alpha (IL1A) (AA 113-271) proteinIL1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 1 alpha (IL1A) (AA 113-271) protein (Fc Tag)IL1A Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 1 alpha (IL1A) (AA 115-270) protein (His tag)IL1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 1 alpha (IL1A) proteinIL1A Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Interleukin 1 alpha (IL1A) (AA 1-271) protein (GST tag)IL1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 1 alpha (IL1A) (AA 172-271) protein (GST tag)IL1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 1 alpha (IL1A) proteinIL1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Interleukin 1 alpha (IL1A) (AA 113-271) protein (His tag)IL1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90% by SDS-PAGE SDS
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
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Buffer
- Lyophilized from 10 mM tris, pH 8.0, with 50 mM NaCl.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- IL1A (Interleukin 1 alpha (IL1A))
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Alternative Name
- IL1 alpha
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Background
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IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine.
Alternative Names: Interleukin 1 alpha protein, Leukocyte Endogenous Mediator protein, MCF protein, EP protein, LAF protein, Hematopoietin-1 protein, Lymphocyte-activating factor protein, IL-1, IL1, IL-1 alpha protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, IL 1 protein, LEM protein, IL 1, IL-1 protein -
Molecular Weight
- 18 kDa
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Pathways
- NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
Target
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