SERPINB2 Protein
Quick Overview for SERPINB2 Protein (ABIN935740)
Target
See all SERPINB2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF NEVGANAVT PMTPENFTSC GFMQQIQKGS YPDAILQAQA ADKIHSSFRS LSSAINASTG N YLLESVNK LFGEKSASFR EEYIRLCQKY YSSEPQAVDF LECAEEARKK INSWVKTQTK GK IPNLLPE GSVDGDTRMV LVNAVYFKGK WKTPFEKKLN GLYPFRVNSA QRTPVQMMYL REK LNIGYI EDLKAQILEL PYAGDVSMFL LLPDEIADVS TGLELLESEI TYDKLNKWTS KDKM AEDEV EVYIPQFKLE EHYELRSILR SMGMEDAFNK GRANFSGMSE RNDLFLSEVF HQAMV DVNE EGTEAAAGTG GVMTGRTGHG GPQFVADHPF LFLIMHKITN CILFFGRFSS P
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Characteristics
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Purified recombinant Human PAI2 protein
Expression System: E.coli
Bioactivity: Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 370C. Half maximal inhibition against 1.0 µg/mL of single chain tPA was obtained at a concentration of 1.0 µg/mL -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 1-415) protein (His tag)
custom-made SERPINB2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 1-415) protein (His tag)custom-made SERPINB2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 1-415) protein (GST tag)SERPINB2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
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Buffer
- Lyophilized from 50 MM CH3COONa, with 100 mM NaCl.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
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Alternative Name
- PAI2
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Target Type
- Amino Acid
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Background
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PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions.
Alternative Names: Plasminogen Activator Inhibitor-2 protein, Urokinase Inhibitor protein, PAI 2, PAI-2 protein, PAI2, PAI-2 protein, PAI 2 protein, PAI-2 -
Pathways
- Autophagy
Target
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