LTA Protein
Quick Overview for LTA Protein (ABIN935844)
Target
See all LTA ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL
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Characteristics
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Purified recombinant Human TNF beta protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the cytolysis of Mouse L929 cells in the presence of Actinomycin-D is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Lymphotoxin-alpha (LTA) (Active) protein
LTA Origin: Chemical Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Lymphotoxin-alpha (LTA) (AA 58-205) protein (His-DYKDDDDK-Strep II Tag)LTA Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Lymphotoxin-alpha (LTA) (AA 34-202) protein (His tag)LTA Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Lymphotoxin-alpha (LTA) (AA 35-205) protein (His tag)LTA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Lymphotoxin-alpha (LTA) (AA 1-205) protein (GST tag)LTA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in Water to a concentration of 0.1-1.0 mg/mL.
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Buffer
- Lyophilized from 10 mM Na3PO4, pH 7.0, with 50 mM NaCl.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- LTA (Lymphotoxin-alpha (LTA))
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Alternative Name
- TNF beta
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Target Type
- Chemical
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Background
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TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.
Alternative Names: LT-alpha protein, TNFSF1 protein, TNF-b protein, Tumor Necrosis Factor-beta protein, TNF-beta protein, Lymphotoxin-alpha protein, TNFb protein -
Molecular Weight
- 18.6 kDa
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Target
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