TIMP2 Protein
Quick Overview for TIMP2 Protein (ABIN935875)
Target
See all TIMP2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MCSCSPVHPQ QAFCNADVVI RAKAVSEKEV DSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHIT LCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIK RSDGSCAWYR GAAPPKQEFL DIEDP
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Characteristics
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Purified recombinant Human TIMP2 protein
Expression System: E.coli
Bioactivity: TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5 µg/mL, when using an MMP-1 concentration of 1.6 µg/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) protein (His tag)
TIMP2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) protein (His tag)TIMP2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Metalloproteinase Inhibitor 2 (TIMP2) protein (Fc Tag)TIMP2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Metalloproteinase Inhibitor 2 (TIMP2) (AA 27-220) protein (GST tag)TIMP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Metalloproteinase Inhibitor 2 (TIMP2) (AA 30-220), (partial) protein (GST tag)TIMP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % ELISA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
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Alternative Name
- TIMP2
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Background
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TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo.
Alternative Names: TIMP 2 protein, Tissue inhibitor of metalloproteinases 2 protein, CSC-21K protein, TIMP2, TIMP-2 protein, TIMP-2 protein, TIMP-2, TIMP 2 -
Molecular Weight
- 21.8 kDa
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Pathways
- cAMP Metabolic Process
Target
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