BAFF Protein (AA 134-285)
Quick Overview for BAFF Protein (AA 134-285) (ABIN987760)
Target
See all BAFF (TNFSF13B) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 134-285
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Characteristics
- ED50< 20 ng/mL, determined by dose-dependent mitogenic activity on human RPMI 8226 cells, corresponding to a specific activity of >5.0 x 10^4 units/mg.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 141-285), (Trimer) protein (His-DYKDDDDK Tag)
TNFSF13B Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 134-285) protein (Fc Tag)TNFSF13B Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 141-285), (Trimer) protein (hFc-DYKDDDDK Tag)TNFSF13B Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 94 % as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (Trimer) protein (His-Avi Tag,Biotin)TNFSF13B Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 94% as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 141-285), (Trimer) protein (His-Avi Tag,DYKDDDDK Tag,Biotin)TNFSF13B Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 1-285) protein (His tag)custom-made TNFSF13B Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 1-309) protein (His tag)custom-made TNFSF13B Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 141-285), (Trimer) protein (His-Avi Tag)TNFSF13B Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 136-285) protein (His-DYKDDDDK-Strep II Tag)TNFSF13B Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (AA 127-309) (Active) proteinTNFSF13B Origin: Mouse Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant human B-Cell Activating Factor (BAFF) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rh-BAFF should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
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Alternative Name
- B-Cell Activating Factor (BAFF)
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Background
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B-cell activating factor, also known as BAFF, TALL-1, TNAK, and zTNF4, is a member of theTNF ligand superfamily designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins lacking a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56 % aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, resting CD4+ T cells, thymus and peripheral blood leukocytes.
Synonyms: BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, B-cell Activating Factor -
Molecular Weight
- 17 kDa, observed by non-reducing SDS-PAGE.
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UniProt
- Q9Y275
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Pathways
- NF-kappaB Signaling, Production of Molecular Mediator of Immune Response
Target
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