BMP7 Protein

Catalog No. ABIN987784

BMP7 protein expressed in Escherichia coli (E. coli).

Quick Overview for BMP7 Protein (ABIN987784)

Target: BMP7 (Bone Morphogenetic Protein 7 (BMP7))

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % by SDS-PAGE and HPLC analyses.

Product Details

Endotoxin Level: Level Less than 1EU/µg of rHuBMP-7 as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at Applications 1. Molecular standard (Western, ELISA) in studying secreted BMP-7,2. Preparing antibodies for BMP-7 monomer, 3. Molecule standard in detecting secreted BMP-7 in reduced SDS-PAGE.

Storage: 4 °C

Target Details

Target: BMP7 (Bone Morphogenetic Protein 7 (BMP7))

Alternative Name: Bone Morphogenetic Protein-7 (BMP-7)

Background: Human BMP-7 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they havesince been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP-7 is synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. Synonym: Bone Morphogenetic Protein-7 (BMP-7), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 30% acetonitrile, 0.1% TFA.

Molecular Weight: Approximately 15.6 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids.

Pathways: Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance